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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2382213Generated: October 29, 2026

Benzylamine → HCID 67337539, compound

https://huagongshe.com/reaction/2382213

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzylamineHCID 7504—
Reactant(+)-(S,R)-6-Fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyranHCID 51698391—
SolventMethanolHCID 887—
ProductHCID 67337539HCID 6733753965.1%

Reaction Steps

(S)-6-fluoro-3,4-dihydro-2-((R)-oxiran-2-yl)-2H-chromene (30 mg, 0.154 mmol) was dissolved in methanol (2 ml) and kept under stirring. benzylamine (40 mg, 0.374 mmol) was added and the reaction mixture left to stir. After checking the reaction outcome, the solution was concentrated under reduced pressure and the crude residue further dried at 30° C. in vacuo to furnish 30 mg of (R)-2-(phenylmethylimino)-1-((S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol as a white solid (64% yield).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08258323B2
Source datasetuspto-grants-2012_09
ORD IDord-e94145a19c6d4ca78d61874ecb229f9f
Source noteuspto-grants-2012_09