HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → HCID 67337539, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | (+)-(S,R)-6-Fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran | HCID 51698391 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67337539 | HCID 67337539 | 65.1% |
Reaction Steps
(S)-6-fluoro-3,4-dihydro-2-((R)-oxiran-2-yl)-2H-chromene (30 mg, 0.154 mmol) was dissolved in methanol (2 ml) and kept under stirring. benzylamine (40 mg, 0.374 mmol) was added and the reaction mixture left to stir. After checking the reaction outcome, the solution was concentrated under reduced pressure and the crude residue further dried at 30° C. in vacuo to furnish 30 mg of (R)-2-(phenylmethylimino)-1-((S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol as a white solid (64% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258323B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-e94145a19c6d4ca78d61874ecb229f9f |
| Source note | uspto-grants-2012_09 |