Acetonitrile → HCID 59993201, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[4-(4-Methoxy-benzenesulfonyl)-piperazin-1-ylmethyl]-3H-quinazolin-4-one (83 mg, 0.2 mmol), cyclopentyl iodide (46 μL, 0.4 mmol), and potassium carbonate (138 mg, 1 mmol) in DMF (1 mL) was heated to 90° C. for 1 day. The reaction mixture was partitioned between dichloromethane and water. The organic layer was concentrated in vacuo and the residue was purified by HPLC (in the absence of TFA) to yield the product. 1H NMR (400 MHz, CDCl3) δ 8.11 (d, J=8.1 Hz, 1H), 7.88 (d, J=8.4 Hz, 1H), 7.78 (t, J=7.6 Hz, 1H), 7.71 (d, J=8.8 Hz, 2H), 7.51 (t, J=7.5 Hz, 1H), 7.00 (d, J=8.8 Hz, 2H), 5.73 (quintet, J=3.0 Hz, 1H), 3.88 (m, 5H), 3.12 (m, 4H), 2.84 (m, 4H), 1.90 (m, 8H); HPLC ret. time 2.85 min, 10-99% CH3CN, 5 min run; ESI-MS m/z 483.5 (M+1)+.

Provenance & Evidence