2-Formylamino-4-methyl-pentanoic Acid 1-(3-hexyl-4-oxo-oxetan-2-ylmethyl)-dodec-4-enyl Ester → 3-Hexyl-4-((R)-2-hydroxytridecyl)-2-oxetanone, (3S,4S)-

Participants

Reaction Steps

Prepared according to representative procedure described in Example 63, above. E/Z-mixture of β-lactone 20a (5.8 mg, 0.016 mmol) and 5 wt % palladium on carbon (5 mg) in 2 mL of THF was stirred at ambient temperature for 12 h under H2 atmosphere. Filtration gave the desired β-lactone 13d (5.9 mg, 99%) as a white solid.

Provenance & Evidence