HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Phenylanthranilic Acid → 1-Acetyl-6-(2-phenylaminobenzoyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Phenylanthranilic Acid | HCID 4386 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(6-amino-2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)ethanone | HCID 2837084 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Acetyl-6-(2-phenylaminobenzoyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline | HCID 17962914 | — |
Reaction Steps
HATU condensation of 1-acetyl-6-amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (15 mg) with N-phenylanthranilic acid (21 mg) and N,N-diisopropylethylamine (33 l) in tetrahydrofuran (1 ml) was performed according to the method described in example 11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258293B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-89ea38094db4447883a82a43c1bb005e |
| Source note | uspto-grants-2012_09 |