Imidazo(1,2-a)pyrimidine → 5H,6H,7H,8H-imidazo[1,2-a]pyrimidine

HRID 2382334Notes

Reaction equation

HRID 2382334 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[N:6][C:5]=12>[Pd].C(O)(=O)C>[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][CH2:7][NH:6][C:5]=12

Participants

4

Reactant 1

HCID 577018Imidazo(1,2-a)pyrimidine

Product 1

HCID 1356254095H,6H,7H,8H-imidazo[1,2-a]pyrimidine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

4.2 g imidazo[1,2-a]pyrimidine hydroperchlorate were heated for 8 h in an acetic acid solution with palladium on activated charcoal, with H2 fed in. Subsequent filtration, removal of the solvent and addition of diethyl ether yielded the 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine hydroacetate in the form of colorless crystals, which were recrystallized from ethanol.

Workup

  1. filtrationSubsequent filtration, removal of the solvent and addition of diethyl ether

Sources & evidence

ORD record
ord-61166817be1b49dd90d7c86f3160bb37
Source dataset
uspto-grants-2012_09
Patent number
US08258501B2

Reaction notes

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