N-[1-(2-pyridinyl)-4-piperidinyl]-1H-imidazole-1-carboxamide → 4-[(Imidazole-1-carbonyl)-amino]-piperidine-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-amide

HRID 2382348Notes

Reaction equation

HRID 2382348 reaction equation
N1(C2C=CC=CN=2)CCC(N[C:8]([N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[O:9])CC1.Cl.Cl.[N:23]1([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][N:40]=2)[CH2:28][CH2:27][CH:26]([NH:29][C:30]([N:32]2[CH2:37][CH2:36][CH:35]([NH2:38])[CH2:34][CH2:33]2)=[O:31])[CH2:25][CH2:24]1>>[N:23]1([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][N:40]=2)[CH2:28][CH2:27][CH:26]([NH:29][C:30]([N:32]2[CH2:37][CH2:36][CH:35]([NH:38][C:8]([N:10]3[CH:14]=[CH:13][N:12]=[CH:11]3)=[O:9])[CH2:34][CH2:33]2)=[O:31])[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 21978278N-[1-(2-pyridinyl)-4-piperidinyl]-1H-imidazole-1-carboxamide2×HCID 666300924-Amino-piperidine-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2']bipy ridinyl-4-yl)-amide dihydrochloride

Product 1

HCID 666303144-[(Imidazole-1-carbonyl)-amino]-piperidine-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-amide

Procedure

The title product is prepared analogously to imidazole-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-amide (Intermediate A1) by replacing 3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-ylamine dihydrochloride with 4-amino-piperidine-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-amide dihydrochloride (Intermediate H2).

Sources & evidence

ORD record
ord-8182ae52b1c54082acbd52675e3c4e10
Source dataset
uspto-grants-2012_09
Patent number
US08258141B2

Reaction notes

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