反应详情

A solution of 4-[1-(2-carbamoyl-phenylcarbamoyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester (20 g, 0.05 mmol, crude from the last step) and MeONa (10 g, 0.19 mol) in MeOH (500 mL) was heated to reflux for 6 hr and the solvent was removed in vacuo. The residue was diluted with water and extracted with EtOAc (300 mL×3), the organic layer was dried with Na2SO4, concentrated and purified by column chromatography to afford the product (2 g, 5%).

1. temperatureto reflux for 6 hr
2. customthe solvent was removed in vacuo
3. additionThe residue was diluted with water
4. extractionextracted with EtOAc (300 mL×3)
5. dry with materialthe organic layer was dried with Na2SO4
6. concentrationconcentrated
7. custompurified by column chromatography