Methyl chloroformate → {(1S,2R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-carbamic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	Methyl chloroformate	HCID 6586	—
Reactant	Cyclobutanecarboxylic acid {(1S,2R,3S,4R)-4-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-amide	HCID 86622641	—
Product	{(1S,2R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-carbamic acid methyl ester	HCID 86632436	—

Reaction Steps

This compound is prepared analogously to cyclobutanecarboxylic acid {(1S,2R,3S,4R)-4-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-amide (Intermediate K) by replacing cyclobutanecarboxylic acid chloride with methylchloroformate.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08258141B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-15cbf79cd1d543368643e245f67d5edc
Source note	uspto-grants-2012_09