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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2382386Generated: November 1, 2026

3-(tert-Butoxy)propionic acid → 3-tert-Butoxy-N-[(1S,2R,3S,4R)-4-(2,6-dichloro-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamide

https://huagongshe.com/reaction/2382386

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(tert-Butoxy)propionic acidHCID 2760949—
Reactant(R)-2-benzyloxy-N-[(1S,2R,3S,4R)-4-(2,6-dichloro-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamideHCID 86647544—
Product3-tert-Butoxy-N-[(1S,2R,3S,4R)-4-(2,6-dichloro-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamideHCID 86647543—

Reaction Steps

The title compound is prepared as described for (R)-2-benzyloxy-N-[(1S,2R,3S,4R)-4-(2,6-dichloro-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamide (Example 181, Step 1), by replacing (R)-2-benzyloxy-propionic acid with 3-tert-butoxypropionic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08258141B2
Source datasetuspto-grants-2012_09
ORD IDord-eb93197bed4e48e0b29572d556ccee08
Source noteuspto-grants-2012_09