反应详情

A mixture of 3-propionylamino-pyrazine-2-carboxylic acid amide (9.7 g, 50 mmol) and Na2CO3 (100 mL, 10%) was refluxed overnight. The water was removed in vacuo and the residue was treated with CH3OH (200 mL). The insoluble salt was filtered and the filtrate was evaporated to give 2-Ethyl-3H-pteridin-4-one as a yellow solid (6.1 g, 69%). 1H NMR (DMSO-d6) δ 8.64 (d, J=2 Hz, 1H), 8.36 (d, J=2 Hz, 1H), 2.52 (q, J=4.5 Hz, 2H), 1.18 (t, J=4.5 Hz, 3H). MS (ESI) m/e (M+1)30: 177.3.

1. temperaturewas refluxed overnight
2. customThe water was removed in vacuo
3. additionthe residue was treated with CH3OH (200 mL)
4. filtrationThe insoluble salt was filtered
5. customthe filtrate was evaporated