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HRID2382447

反应详情

EQUATION

反应方程式

HRID 2382447 的结构方程式

REACTANTS

反应物

3
结构：C1CCN([C@@H]2CCNC2)C1
HCID7176272

(3R)-3-(PYRROLIDIN-1-YL)PYRROLIDINE

C8H16N2

2 次

结构：N[C@@H]1CCN(c2nc(NCC(c3ccccc3)c3ccccc3)c3ncn([C@@H]4C[C@H](NC(=O)COCc5ccccc5)[C@@H](O)[C@H]4O)c3n2)C1.O=C(O)C(F)(F)F
HCID66630722

未命名化合物

结构：CCC(=O)N[C@H]1C[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(Cl)nc32)[C@H](O)[C@@H]1O
HCID86622630

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CCC(=O)N[C@H]1C[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(N4CC[C@@H](N5CCCC5)C4)nc32)[C@H](O)[C@@H]1O.Cl
HCID66630578

未命名化合物

PROCEDURE

实验过程

The title compound is prepared analogously to N-{(1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-2-benzyloxy-acetamide trifluoroacetate (Example 1 step 2) by replacing 2-benzyloxy-N-{(1S,2R,3S,4R)-4-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-acetamide with N-{(1S,2R,3S,4R)-4-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide (Intermediate J) and by replacing (3R)-3-aminopyrrolidine with (R)-[1,3′]bipyrrolidinyl (Intermediate N). (MH+ 625.4)