HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2382463Generated: November 1, 2026
Phenyl pyridin-3-ylcarbamate → HCID 66630596, compound
https://huagongshe.com/reaction/2382463
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenyl pyridin-3-ylcarbamate | HCID 6935890 | — |
| Reactant | (R)-N-{(1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-2-benzyloxy-propionamide | HCID 66630466 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 66630596 | HCID 66630596 | — |
Reaction Steps
A solution comprising (R)—N-{(1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-2-benzyloxy-propionamide (1 equivalent) and pyridin-3-yl-carbamic acid phenyl ester (Intermediate ZB) (1 equivalent) in NMP is stirred at 100° C. for 1 hour. The solvent is removed in vacuo and the title compound is obtained after purification by column chromatography/crystallisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08258141B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-877fe4f47827474ba8ec6672305bc95d |
|---|
| Source note | uspto-grants-2012_09 |
|---|
