HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2382485Generated: November 1, 2026
Triphenylphosphine → HCID 66630707, compound
https://huagongshe.com/reaction/2382485
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Methyl 4-prop-2-ynylcyclohexanecarboxylate | HCID 10749876 | — |
| Reactant | N-[(1S,2R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl]-propionamide | HCID 86622630 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | triethylamine N,N-dimethylformamide | HCID 22056947 | — |
| Product | HCID 66630707 | HCID 66630707 | — |
Reaction Steps
The title compound is prepared by combining N-{(1S,2R,3S,4R)-4-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide (intermediate J), 4-prop-2-ynyl-cyclohexanecarboxylic acid methyl ester (prepared as described by Rieger J. M., Brown M. L., Sullivan G. W., Linden J. and Macdonald T. L.; J. Med. Chem. (2001), 44, 531-539), copper (I) iodide, triphenylphosphine and dichlorobis(triphenylphosphine)palladium(II) in a 2:1 mixture of triethylamine/DMF, and heating by microwave irradiation for 3600 seconds at 120° C. Purification by column chromatography affords the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08258141B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-679f5b8190a14c49a5a63688cc996842 |
|---|
| Source note | uspto-grants-2012_09 |
|---|
