Triamcinolone Acetonide → Triamcinolone

HRID 2382516Notes

Reaction equation

HRID 2382516 reaction equation
[CH3:1][C@@:2]12[C@:10]3([C:16]([CH2:18][OH:19])=[O:17])[O:11]C(C)(C)[O:13][C@@H:9]3[CH2:8][C@H:7]1[C@@H:6]1[CH2:20][CH2:21][C:22]3[C@@:28]([CH3:29])([C@@:5]1([F:30])[C@@H:4]([OH:31])[CH2:3]2)[CH:27]=[CH:26][C:24](=[O:25])[CH:23]=3.C[C@@]12[C@@](O)(C(CO)=O)[C@H](O)C[C@H]1[C@@H]1C[C@H](F)C3[C@@](C)([C@@]1(F)[C@@H](O)C2)C=CC(=O)C=3>>[CH3:1][C@@:2]12[C@@:10]([OH:11])([C:16]([CH2:18][OH:19])=[O:17])[C@H:9]([OH:13])[CH2:8][C@H:7]1[C@@H:6]1[CH2:20][CH2:21][C:22]3[C@@:28]([CH3:29])([C@@:5]1([F:30])[C@@H:4]([OH:31])[CH2:3]2)[CH:27]=[CH:26][C:24](=[O:25])[CH:23]=3

Participants

3

Reactant 2

HCID 6436Triamcinolone AcetonideHCID 91488Fluocinolone

Product 1

HCID 31307Triamcinolone

Procedure

Triamcinolone acetonide was combined with a polymer in a stainless steel mortar and mixed using the Turbula shaker set at 96 RPM for 15 minutes. The powder of the fluocinolone and polymer was scraped off the walls of the steel mortar and then mixed again for an additional 15 minutes. The powder blend was heated at temperatures ranging from 110° C. to 160° C., depending on the polymer used, for a total of 30 minutes, forming a polymer/drug melt. The melt was pelletized, then loaded into the barrel and extruded into filaments, and finally the filaments were cut into about 0.5 mg or about 1 mg size implants. The implants had a weight range from about 450 μg to about 550 μg, or from about 900 μg to about 1100 μg. The 1 mg size implants had a length of about 2 mm and a diameter of about 0.72 mm.

Workup

  1. additionmixed
  2. additionmixed again for an additional 15 minutes
  3. temperatureThe powder blend was heated at temperatures
  4. customranging from 110° C. to 160° C.
  5. customused, for a total of 30 minutes
  6. customforming a polymer/drug

Sources & evidence

ORD record
ord-2f29e094eb804e24b4f04d747423e709
Source dataset
uspto-grants-2012_09
Patent number
US08263110B2

Reaction notes

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