Hydrochloric Acid → HCID 25052782, compound

Participants

Reaction Steps

To a solution of 5-[3-(3-Hydroxy-phenoxy)-azetidin-1-yl]-5-methyl-2,2-diphenyl-hexanoic acid amide (3.5 g, 7.8 mmol) in methanol (30 ml) was added a 1.25M HCl solution in methanol (6.3 ml, 7.8 mmol). The solution was stirred at rt for 3 h then placed in an ice bath for 6 h. As no precipitation was noticed, the solution was concentrated under reduced pressure to remove some solvent (17 ml) and the resulting solution stirred at rt for 16 h to afford a precipitate. The suspension was filtered, washed with methanol (10 ml) and dried in a vacuum oven at 40° C. to give 5-[3-(3-Hydroxy-phenoxy)-azetidin-1-yl]-5-methyl-2,2-diphenyl-hexanoic acid amide hydrochloride as a white solid, 2.55 g (67%).

Provenance & Evidence