Maleic Acid → HCID 24899060, compound

Participants

Reaction Steps

5-(4-Pyridine-2-yl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-7-ylmethyl)-thiazolidine-2,4-dione [compound of Example 4] (260.2 mg, 0.730 mmol) was dissolved in methanol (20 mL). To this solution, maleic acid (85 mg, 0.730 mmol) was added under stirring at room temperature to give a turbid solution. On warming to 40° C., both the components dissolved completely. It was then diluted with methanol (10 mL) and stirred overnight. The reaction mixture was filtered and concentrated to give a yellow oil. The oil was dried under high vacuum at 40° C. for 2 hours to give a yellow crystalline solid.

Provenance & Evidence