反应详情

温度

100 °C

To 2-methylsulfanyl-benzooxazole [compound of Step I] (25 g, 150 mmol), ethanolamine (253 g, 250 mL) was added and the reaction mixture was heated at 100° C. for 1.5 hours. The reaction mixture was poured on crushed ice-water mixture and extracted with ethyl acetate (3×1 L). The ethyl acetate layer was washed with water and brine, dried over anhydrous sodium sulfate and concentrated to give 2-(benzooxazol-2-ylamino)-ethanol.

1. additionThe reaction mixture was poured
2. extractionextracted with ethyl acetate (3×1 L)
3. washThe ethyl acetate layer was washed with water and brine
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated