Thiazolidinedione → HCID 74348953, compound

Participants

Reaction Steps

To 4-benzooxazol-2-yl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine-7-carbaldehyde [compound of Step VI] (0.176 g, 0.6 mmol) taken in toluene (25 mL) were added 2,4-thiazolidine dione (0.105 g, 0.9 mmol) and catalytic amount of piperidinium acetate (0.025 g). The resulting mixture was refluxed under Dean Stark conditions for 1.5 hours and then cooled in an ice-bath. The precipitate was filtered and washed with toluene and petroleum ether to give 5-(4-benzooxazol-2-yl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-7-ylmethylene)-thiazolidine-2,4-dione.

Provenance & Evidence