Water → HCID 24899058, compound

Participants

Reaction Conditions

Reaction Steps

5-(4-Benzooxazol-2-yl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-7-ylmethylene)-thiazolidine-2,4-dione [compound of Example 6] (0.118 g, 0.3 mmol) was taken in 1,2-dimethoxyethane (40 mL) under nitrogen. The mixture was cooled to 7-10° C. by using dry ice-acetone bath, freshly prepared Al-amalgam strips and water (0.54 mL, 30 mmol) were added and the reaction mixture was stirred for 4 hours. The reaction mixture was then filtered through a celite bed and washed with 1,2-dimethoxyethane. The organic layer was concentrated under high vacuum and purified using silica gel column in 50% ethyl acetate in petroleum ether. The product obtained after concentration was washed with 2% ethyl acetate in petroleum ether, to give 5-(4-benzooxazol-2-yl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-7-ylmethyl)-thiazolidine-2,4-dione.

Provenance & Evidence