Maleic Acid → HCID 86654537, compound

Participants

Reaction Steps

To a mixture of 5-(4-Pyridin-2-yl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-7-ylmethylene)-thiazolidine-2,4-dione [compound of Example 3] (35.3 mg, 0.1 mmol) and maleic acid (11.6 mg, 0.1 mmol) in a 100 mL two necked round bottomed flask was added 30 mL methanol:dichloromethane (2:1). The mixture was heated until a clear solution was obtained. The solution was stirred overnight (16 hours) and concentrated to give a solid which was recrystallized from methanol:dichloromethane:petroleum ether to give crystals of 5-(4-Pyridin-2-yl-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepin-7-ylmethylene)-thiazolidine-2,4-dione maleate. mp: 224-226° C.

Provenance & Evidence