4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)pyrimidin-2-amine → Pyridine-3-sulfonic acid [5-(2-amino-4-methyl-pyrimidin-5-yl)-2-chlorophenyl]-amide

HRID 2382605Notes

Reaction equation

HRID 2382605 reaction equation
[CH3:1][C:2]1[C:7](B2OC(C)(C)C(C)(C)O2)=[CH:6][N:5]=[C:4]([NH2:17])[N:3]=1.Br[C:19]1[CH:20]=[CH:21][C:22]([Cl:35])=[C:23]([NH:25][S:26]([C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)(=[O:28])=[O:27])[CH:24]=1>>[NH2:17][C:4]1[N:3]=[C:2]([CH3:1])[C:7]([C:19]2[CH:20]=[CH:21][C:22]([Cl:35])=[C:23]([NH:25][S:26]([C:29]3[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=3)(=[O:28])=[O:27])[CH:24]=2)=[CH:6][N:5]=1

Participants

3

Reactant 2

HCID 529879064-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)pyrimidin-2-amine2×HCID 62907758Pyridine-3-sulfonic acid [5-bromo-2-chloro-phenyl]-amide

Product 1

HCID 86761609Pyridine-3-sulfonic acid [5-(2-amino-4-methyl-pyrimidin-5-yl)-2-chlorophenyl]-amide

Procedure

This compound is prepared as described for Example 3-25 (step 2) from 4-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl]-pyrimidin-2-ylamine (Intermediate G) and pyridine-3-sulfonic acid [5-bromo-2-chloro-phenyl]-amide.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-2c8e54b493084eb09da3bfc11f6005e4
Source dataset
uspto-grants-2012_09
Patent number
US08263585B2

Reaction notes

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