Aniline → N-Methyl 3-fuorobenzamide

HRID 2382639Notes

Reaction equation

HRID 2382639 reaction equation
ClC1N=C(N[C:9]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:10]=2[C:11]([NH:13][CH3:14])=[O:12])C(Cl)=CN=1.NC1C=CC=CC=1>>[F:19][C:16]1[CH:17]=[CH:18][CH:9]=[C:10]([CH:15]=1)[C:11]([NH:13][CH3:14])=[O:12]

Participants

3

Reactant 2

HCID 6115AnilineHCID 85997906HCID 85997906, compound

Product 1

HCID 4133782N-Methyl 3-fuorobenzamide

Procedure

The following 2-(5-Chloro-2-(subst. phenylamino)-pyrimidin-4-ylamino)-5-fluoro-N-methyl-benzamide are prepared from 2-(2,5-Dichloro-pyrimidin-4-ylamino)-5-fluoro-N-methyl-benzamide and the corresponding aniline following the procedure of Example 2:

Sources & evidence

ORD record
ord-0e959eb585a14603867cafc4a893d66f
Source dataset
uspto-grants-2012_09
Patent number
US08263590B2

Reaction notes

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