Ethyl isothiocyanatoformate → Ethyl({[6-(3-thienyl)pyridin-2-yl]amino}carbonothioyl)carbamate

Participants

Reaction Steps

A solution of 6-(3-thienyl)pyridin-2-amine (3.70 g; 21.0 mmol; 1.0 eq.) and ethoxycarbonyl isothiocyanate (2.73 mL; 24.1 mmol; 1.15 eq.) in dioxane (100 mL) was stirred at rt overnight. The precipitate formed was filtered and washed with c-Hex to give the title compound as a white solid (4.73 g; 73%). HPLC, Rt: 4.26 min. (purity 99.9%). LC/MS, M+(ESI): 308.3.

Provenance & Evidence