Cycloheptylamine → HCID 25216187, compound

HRID 2382767Notes

Reaction equation

HRID 2382767 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH2:11])[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[CH:12]1([NH2:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>>[CH:12]1([NH:19][C:2]2[N:7]3[N:8]=[C:9]([NH2:11])[N:10]=[C:6]3[CH:5]=[CH:4][CH:3]=2)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 2899CycloheptylamineHCID 214644135-Chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 25216187HCID 25216187, compoundYield 59%

Conditions

Temperature
180 °C

Procedure

The title compound was prepared following procedure described for intermediate A9, but starting from 5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A4), 2.88 g; 17.1 mmol; 1.0 eq.) and cycloheptylamine (14 mL) and heated at 180° C. for 1 h under microwave radiation to give the title compound as a beige oil (2.48 g; 59%). HPLC, Rt: 2.90 min. (purity 97.2%). LC/MS, M+(ESI): 292.9.

Workup

  1. customThe title compound was prepared following procedure

Sources & evidence

ORD record
ord-7326bd524f0742c0b4abe4664fa9e5b1
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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