Cyclohexylamine → HCID 25216191, compound

HRID 2382771Notes

Reaction equation

HRID 2382771 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:9]=[C:10]([NH2:12])[N:11]=2)[C:7]=1Cl.[CH:13]1([NH2:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:9]=[C:10]([NH2:12])[N:11]=2)[C:7]=1[NH:19][CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 59437526HCID 59437526, compound

Product 1

HCID 25216191HCID 25216191, compound

Procedure

The title compound was prepared following procedure described for intermediate A9 but starting from 6-bromo-5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-amine (3.0 g; 12.1 mmol; 1.0 eq.) and cyclohexylamine (12.0 mL; 104.9 mmol; 8.65 eq.) to give the title compound as a dark foam (2.5 g, 66%). HPLC, Rt: 3.21 min. (purity 76.6%). LC/MS, M+(ESI): 310.0.

Workup

  1. customThe title compound was prepared following procedure

Sources & evidence

ORD record
ord-24607428f37e487a87d130611a08fd53
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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