反应详情

温度

120 °C

A suspension of 5-chloro-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A7), 183.00 mg; 0.77 mmol; 1.00 eq.) and isopropylamine (664.58 μl; 7.74 mmol; 10.00 eq.) in n-butanol (1.50 mL) was heated at 120° C. for 1 h30 under MW irradiation. The reaction mixture was then concentrated under vacuum till dryness. The solid obtained was triturated in water/MTBE and filtered. The solid which precipitated in mother liquor was finally filtered, washed with water and dried under vacuum at 40° C. to give the title compound as an off-white solid (122 mg, 61%). HPLC, Rt: 2.64 min. (purity 86.5%). LC/MS, M+(ESI): 259.9, M−(ESI): 257.9.

1. concentrationThe reaction mixture was then concentrated under vacuum till dryness
2. customThe solid obtained
3. customwas triturated in water/MTBE
4. filtrationfiltered
5. customThe solid which precipitated in mother liquor
6. filtrationwas finally filtered
7. washwashed with water
8. customdried under vacuum at 40° C.