3-Pyridinecarbonyl chloride, hydrochloride (1:1) → N-(5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide

Participants

Reaction Steps

The title compound was prepared following procedure described for intermediate B1, but starting from 5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A4), 14.60 g; 86.60 mmol; 1.0 eq.) and nicotinoyl chloride hydrochloride (18.5 g; 104 mmol; 1.2 eq.) as a greenish solid (20.61 g; 87%). HPLC, Rt: 1.19 min. (purity 99.4%). LC/MS, M+(ESI): 274.3, M+(ESI): 272.3.

Provenance & Evidence