3-Pyridinecarbonyl chloride, hydrochloride (1:1) → N-(5,7-dichloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide

Participants

Reaction Steps

The title compound was prepared following procedure described for intermediate B1, but starting from 5,7-dichloro[1,2,4]triazolo[1,5-a]pyridin-2-amine (1.00 g; 4.93 mmol; 1.00 eq.) and nicotinoyl chloride hydrochloride (1052.16 mg; 5.91 mmol; 1.20 eq.) as a yellowish solid (1.06 g, 70%). HPLC, Rt 1.61 min. (purity 92.4%). LC/MS, M+(ESI): 307.7, M−(ESI): 305.8.

Provenance & Evidence