3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 25212772, compound

HRID 2382785Notes

Reaction equation

HRID 2382785 reaction equation
[Cl:1][C:2]1[N:7]2[N:8]=[C:9]([NH2:11])[N:10]=[C:6]2[CH:5]=[C:4]([CH3:12])[CH:3]=1.Cl.[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[N:17][CH:16]=1>>[Cl:1][C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:14](=[O:21])[C:15]3[CH:20]=[CH:19][CH:18]=[N:17][CH:16]=3)[N:10]=[C:6]2[CH:5]=[C:4]([CH3:12])[CH:3]=1

Participants

3

Reactant 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 25212771HCID 25212771, compound

Product 1

HCID 25212772HCID 25212772, compound

Procedure

The title compound was prepared following procedure described for intermediate B1, but starting from 5-chloro-7-methyl[1,2,4]triazolo[1,5-a]pyridin-2-amine (282 mg; 1.54 mmol; 1.0 eq.) and nicotinoyl chloride hydrochloride (330 mg; 1.85 mmol; 1.20 eq.) as a off-white powder (244 mg, 55%). HPLC, Rt: 1.51 min. (purity 90.4%). LC/MS, M+(ESI): 288.1, M−(ESI): 286.2.

Sources & evidence

ORD record
ord-2fbc3ac3bbfb40a183cc35b7285d267d
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

Loading…