Ethyl 3-chloro-3-oxopropionate → HCID 59437525, compound

HRID 2382789Notes

Reaction equation

HRID 2382789 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.Cl[C:17](=[O:24])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH:15][C:17](=[O:24])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 118931Ethyl 3-chloro-3-oxopropionateHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 59437525HCID 59437525, compound

Procedure

The title compound was prepared following procedure described for intermediate B1, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 660 mg; 0.30 mmol; 1.0 eq.) and ethyl 3-chloro-3-oxopropionate (90 mg, 0.60 mmol; 2.0 eq.) as a white powder (42 mg, 45%). HPLC, Rt: 2.72 min. (purity 90.8%). LC/MS, M+(ESI): 315.3, M−(ESI): 313.3.

Sources & evidence

ORD record
ord-9b04bccbc6024ac480cafb2781cdf0bb
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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