6-Chloronicotinoyl Chloride → HCID 59437475, compound

HRID 2382791Notes

Reaction equation

HRID 2382791 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][N:18]=1>>[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([NH:15][C:13]2[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=[C:6]([C:3]4[CH:4]=[CH:5][O:1][CH:2]=4)[N:11]3[N:12]=2)=[O:22])=[CH:19][N:18]=1

Participants

3

Reactant 2

HCID 27821656-Chloronicotinoyl ChlorideHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 59437475HCID 59437475, compound

Procedure

The title compound was prepared following procedure described for intermediate B1, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 660 mg; 0.30 mmol; 1.0 eq.) and 6-chloronicotinoyl chloride (65 mg, 0.60 mmol; 2.0 eq.) as a white powder (47.7 mg, 47%). HPLC, Rt: 3.00 min. (purity 98.6%). LC/MS, M+(ESI): 340.2, M−(ESI): 338.2.

Sources & evidence

ORD record
ord-6cb6066bd081492aa83c7a2f4abd076f
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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