Butanoic acid, 4-chloro-4-oxo-, methyl ester → Methyl 4-{[5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-4-oxobutanoate

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Reaction Steps

The title compound was prepared following procedure described for intermediate B1, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 660 mg; 0.30 mmol; 1.0 eq.) and 3-carbomethoxypropionyl chloride (65 mg, 0.60 mmol; 2.0 eq.) as a white powder (83.5 mg, 88%). HPLC, Rt: 2.40 min. (purity 95.4%). LC/MS, M−(ESI): 313.2.

Provenance & Evidence