m-Anisoyl chloride → HCID 136063643, compound

Participants

Reaction Steps

The title compound was prepared following procedure described for intermediate B1, but starting from tert-butyl 2-(2-amino[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-pyrrole-1-carboxylate ((A6), 50 mg; 0.17 mmol; 1.0 eq.) and m-anisoyl chloride (57 mg; 0.33 mmol; 2.0 eq.). Further treatment with a DCM/TFA solution (2:1) and purification by flash chromatography on silica (EtOAc/c-Hex, gradient from 50:60 to 80:20) gave the title compound as a white solid (23.1 mg, 41%). HPLC, Rt: 3.40 min. (purity 94.7%). LC/MS, M+(ESI): 334.3, M+(ESI): 332.1

Provenance & Evidence