Benzoyl chloride → HCID 136063645, compound

HRID 2382795Notes

Reaction equation

HRID 2382795 reaction equation
[NH2:1][C:2]1[N:22]=[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C:10]3[N:11](C(OC(C)(C)C)=O)[CH:12]=[CH:13][CH:14]=3)[N:4]2[N:3]=1.[C:23](Cl)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[NH:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:9]1[N:4]2[N:3]=[C:2]([NH:1][C:23](=[O:30])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[N:22]=[C:5]2[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 25216183HCID 25216183, compound

Product 1

HCID 136063645HCID 136063645, compound

Procedure

The title compound was prepared following procedure and work up described for example 9, but starting from tert-butyl 2-(2-amino[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-pyrrole-1-carboxylate ((A6), 50 mg; 0.17 mmol; 1.0 eq.) and benzoyl chloride (47 mg; 0.33 mmol; 2.0 eq.) as a white solid (22.7 mg, 45%). HPLC, Rt: 3.23 min. (purity 91.6%). LC/MS, M+(ESI): 304.3, M−(ESI): 302.3.

Sources & evidence

ORD record
ord-0e3acf8b617648f8bc45776ee136036f
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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