3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 136063644, compound

HRID 2382797Notes

Reaction equation

HRID 2382797 reaction equation
[NH2:1][C:2]1[N:22]=[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C:10]3[N:11](C(OC(C)(C)C)=O)[CH:12]=[CH:13][CH:14]=3)[N:4]2[N:3]=1.Cl.[C:24](Cl)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[N:27][CH:26]=1>>[NH:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:9]1[N:4]2[N:3]=[C:2]([NH:1][C:24](=[O:31])[C:25]3[CH:30]=[CH:29][CH:28]=[N:27][CH:26]=3)[N:22]=[C:5]2[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 25216183HCID 25216183, compound

Product 1

HCID 136063644HCID 136063644, compound

Procedure

The title compound was prepared following procedure described for example 9, but starting from tert-butyl 2-(2-amino[1,2,4]triazolo[1,5-a]pyridin-5-yl)-1H-pyrrole-1-carboxylate ((A6), 360 mg; 1.20 mmol; 1.0 eq.) and nicotinoyl chloride hydrochloride (428 mg; 2.41 mmol; 2.0 eq.) as a brown powder (245 mg, 67%). HPLC, Rt: 2.14 min. (purity 100.0%). LC/MS, M−(ESI): 303.3.

Sources & evidence

ORD record
ord-b473245d15724847996a8e45539fb589
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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