Thiophene-3-boronic acid → N-[6-(3-thienyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide

Participants

Reaction Steps

The title compound was prepared following procedure described for intermediate A1 step a), but starting from N-(6-bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide ((B6), 75 mg; 0.24 mmol; 1.0 eq.) and 3-thienylboronic acid (60 mg; 0.47 mmol; 2.0 eq.). Purification by flash chromatography on silica (MeOH/EtOAc, 5:95) gave the title compound as a beige powder (18.1 mg, 23%). HPLC, Rt: 2.13 min. (purity 94.3%). LC/MS, M+(ESI): 322.3, M−(ESI): 320.2.

Provenance & Evidence