2-Thiopheneacetyl chloride → HCID 25213270, compound

HRID 2382804Notes

Reaction equation

HRID 2382804 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[S:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[CH2:21][C:22](Cl)=[O:23]>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH:15][C:22](=[O:23])[CH2:21][C:17]4[S:16][CH:20]=[CH:19][CH:18]=4)[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 1623622-Thiopheneacetyl chlorideHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 25213270HCID 25213270, compound

Procedure

The title compound was prepared following procedure and work up described for example 19, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 50 mg; 0.25 mmol; 1.0 eq.) and 2-thiopheneacetyl chloride (80 mg; 0.50 mmol; 2.0 eq.) as a white powder (30.9 mg, 38%). HPLC, Rt: 3.28 min. (purity 96.6%). LC/MS, M+(ESI): 357.2, M−(ESI): 355.2.

Sources & evidence

ORD record
ord-e34415b24460497fa0aa357d566d87af
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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