Cyclopentanecarbonyl chloride → HCID 59437462, compound

HRID 2382805Notes

Reaction equation

HRID 2382805 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[CH:16]1([C:21](Cl)=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17]1>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH:15][C:21]([CH:16]4[CH2:20][CH2:19][CH2:18][CH2:17]4)=[O:22])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 78284Cyclopentanecarbonyl chlorideHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 59437462HCID 59437462, compound

Procedure

The title compound was prepared following procedure and work up described for example 19, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 50 mg; 0.25 mmol; 1.0 eq.) and cyclopentanecarbonyl chloride (66 mg; 0.50 mmol; 2.0 eq.) as a white powder (64.1 mg, 86%). HPLC, Rt: 3.11 min. (purity 82.7%). LC/MS, M+(ESI): 297.4, M−(ESI): 295.3.

Sources & evidence

ORD record
ord-39dec1a441124632ae22c535df1c3285
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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