Quinoxaline-6-carbonyl chloride → N-[5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]quinoxaline-6-carboxamide

HRID 2382808Notes

Reaction equation

HRID 2382808 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[N:16]1[C:25]2[C:20](=[CH:21][C:22]([C:26](Cl)=[O:27])=[CH:23][CH:24]=2)[N:19]=[CH:18][CH:17]=1>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH:15][C:26]([C:22]4[CH:21]=[C:20]5[C:25](=[CH:24][CH:23]=4)[N:16]=[CH:17][CH:18]=[N:19]5)=[O:27])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 2776328Quinoxaline-6-carbonyl chlorideHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 25213273N-[5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]quinoxaline-6-carboxamide

Procedure

The title compound was prepared following procedure and work up described for example 19, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 50 mg; 0.25 mmol; 1.0 eq.) and 6-quinoxalinecarbonyl chloride (96 mg; 0.50 mmol; 2.0 eq.) as a white powder (47.5 mg, 53%). HPLC, Rt: 2.73 min. (purity 62.3%). LC/MS, M+(ESI): 357.4, M−(ESI): 355.3.

Sources & evidence

ORD record
ord-09fd54c1514e43c7b701d5815580ae94
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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