3-Aminophenylboronic acid → HCID 25213275, compound

Participants

Reaction Steps

The title compound was prepared following procedure described for intermediate A1 step a) but starting from N-(6-bromo[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide ((B6), 75 mg; 0.24 mmol; 1.0 eq.) and 3-aminobenzeneboronic acid (64 mg; 0.47 mmol; 2.0 eq.). Purification by flash chromatography on silica (MeOH/DCM, gradient from 0:100 to 10:90) gave the title compound as a dark red solid (31 mg, 40%). HPLC, Rt: 1.07 min. (purity 96.3%). LC/MS, M+(ESI): 331.4, M−(ESI): 329.4.

Provenance & Evidence