Isoxazole-5-carbonyl chloride → HCID 25213506, compound

HRID 2382812Notes

Reaction equation

HRID 2382812 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[O:16]1[C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=[N:17]1>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH:15][C:21]([C:20]4[O:16][N:17]=[CH:18][CH:19]=4)=[O:22])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 2736707Isoxazole-5-carbonyl chlorideHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 25213506HCID 25213506, compound

Procedure

The title compound was prepared following procedure described for example 19, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 50 mg; 0.25 mmol; 1.0 eq.) and isoxazole-5-carbonyl chloride (49 mg; 0.37 mmol; 1.5 eq.) as a white powder (19.4 mg, 26%). HPLC, Rt: 2.62 min. (purity 95.3%). LC/MS, M+(ESI): 296.4, M−(ESI): 294.3.

Sources & evidence

ORD record
ord-05dc90485cb64c18a9d8df8059e767f8
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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