3,5-Dimethoxybenzoyl chloride → HCID 25213508, compound

HRID 2382816Notes

Reaction equation

HRID 2382816 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:24]=[C:25]([O:27][CH3:28])[CH:26]=1)[C:21](Cl)=[O:22]>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH:15][C:21](=[O:22])[C:20]4[CH:24]=[C:25]([O:27][CH3:28])[CH:26]=[C:18]([O:17][CH3:16])[CH:19]=4)[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 870033,5-Dimethoxybenzoyl chlorideHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 25213508HCID 25213508, compound

Procedure

The title compound was prepared following procedure described for intermediate B1, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 50 mg; 0.25 mmol; 1.0 eq.) and 3,5-dimethoxybenzoyl chloride (60 mg; 0.30 mmol; 1.2 eq.) as a white powder (42.9 mg; 47%). HPLC, Rt: 3.51 min. (purity 95.3%). LC/MS, M+(ESI): 365.3, M−(ESI): 363.3.

Sources & evidence

ORD record
ord-82bae045f37b43d081a1c3db6c60b99f
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

Loading…