1-(4-Chlorophenyl)cyclopentanecarbonyl chloride → HCID 59437558, compound

HRID 2382818Notes

Reaction equation

HRID 2382818 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2([C:28](Cl)=[O:29])[CH2:27][CH2:26][CH2:25][CH2:24]2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2([C:28]([NH:15][C:13]3[N:14]=[C:10]4[CH:9]=[CH:8][CH:7]=[C:6]([C:3]5[CH:4]=[CH:5][O:1][CH:2]=5)[N:11]4[N:12]=3)=[O:29])[CH2:27][CH2:26][CH2:25][CH2:24]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 27237741-(4-Chlorophenyl)cyclopentanecarbonyl chlorideHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 59437558HCID 59437558, compound

Procedure

The title compound was prepared following procedure described for intermediate B1, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 50 mg; 0.25 mmol; 1.0 eq.) and 1-(4-chlorophenyl)-1-cyclopentanecarbonyl chloride (Lancaster, 91 mg; 0.37 mmol; 1.5 eq.) as a white foam (61.1 mg, 60%). HPLC, Rt: 4.64 min. (purity 73.4%). LC/MS, M+(ESI): 407.4, M−(ESI): 405.4.

Sources & evidence

ORD record
ord-4492acb5975843dabee4870dcb513845
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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