3-Furoyl chloride → N-[5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-furamide

HRID 2382820Notes

Reaction equation

HRID 2382820 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[O:16]1[CH:20]=[CH:19][C:18]([C:21](Cl)=[O:22])=[CH:17]1>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH:15][C:21]([C:18]4[CH:19]=[CH:20][O:16][CH:17]=4)=[O:22])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 27761233-Furoyl chlorideHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 25213510N-[5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-furamide

Procedure

The title compound was prepared following procedure and work up described for example 19, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 50 mg; 0.25 mmol; 1.0 eq.) and 3-furoyl chloride (39 mg; 0.3 mmol; 1.2 eq.) as a white powder (45.3 mg, 61%). HPLC, Rt: 2.65 min. (purity 97.5%). LC/MS, M+(ESI): 295.4, M−(ESI): 293.4.

Sources & evidence

ORD record
ord-ee98dd8042514e3ea8937b8b4b774d33
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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