3-Pyridinecarbonyl chloride, hydrochloride (1:1) → N-[5-(3-thienyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide

Participants

Reaction Steps

The title compound was prepared following procedure described for example 2, but starting from 5-(3-thienyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A1), 82 mg; 0.38 mmol; 1.5 eq.) and nicotinoyl chloride hydrochloride (55 mg; 0.3 mmol; 1.2 eq.) as a beige solid (21 mg, 26%). HPLC, Rt: 2.15 min. (purity 97.3%). LC/MS, M+(ESI): 322.0, M−(ESI): 320.0.

Provenance & Evidence