3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 25213748, compound

Participants

Reaction Steps

The title compound was prepared following procedure described for example 2, but starting from [1,2,4]triazolo[1,5-a]quinolin-2-amine ((A13), 67 mg; 0.37 mmol; 1.5 eq.) and nicotinoyl chloride hydrochloride (80 mg; 0.44 mmol; 1.2 eq.). Purification by flash chromatography on silica (DCM/MeOH, gradient from 98:2 to 95:5) gave the title compound as an orange oil (27 mg, 38%). HPLC, Rt: 1.83 min. (purity 97.9%). LC/MS, M+(ESI): 290.0, M−(ESI): 288.0.

Provenance & Evidence