Oxiniacic Acid → N-[5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide 1-oxide

HRID 2382826Notes

Reaction equation

HRID 2382826 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[C:16](O)(=[O:24])[C:17]1[CH:22]=[CH:21][CH:20]=[N+:19]([O-:23])[CH:18]=1>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH:15][C:16](=[O:24])[C:17]4[CH:22]=[CH:21][CH:20]=[N+:19]([O-:23])[CH:18]=4)[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 16976Oxiniacic AcidHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 25213750N-[5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]nicotinamide 1-oxide

Procedure

The title compound was prepared following procedure described for example 2, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 100 mg; 0.50 mmol; 1.0 eq.) and nicotinic acid N-oxide (83 mg, 0.6 mmol, 1.2 eq.) as a light yellow solid (37.2 mg, 23%). HPLC, Rt: 1.98 min. (purity 98.8%). LC/MS, M+(ESI): 322.1, M−(ESI): 320.1.

Sources & evidence

ORD record
ord-3b42bfe6267946898d6e2022ff72c011
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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