Cyclohexylamine → HCID 25213974, compound

HRID 2382830Notes

Reaction equation

HRID 2382830 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[CH:20]1([NH2:26])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH:20]1([NH:26][C:2]2[N:7]3[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[N:10]=[C:6]3[CH:5]=[CH:4][CH:3]=2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 25212515HCID 25212515, compound

Product 1

HCID 25213974HCID 25213974, compound

Procedure

The title compound was prepared following procedure described for example 30 but starting from N-(5 chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzamide ((B3), 50 mg; 0.18 mmol; 1.0 eq.) and cyclohexylamine (1.0 mL) as an off-white powder (50 mg, 81%). HPLC, Rt: 3.33 min. (purity 94.3%). LC/MS, M+(ESI): 336.2, M−(ESI): 334.1.

Sources & evidence

ORD record
ord-060bebffd7e0460d9aedc89cb6e72c90
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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