2-Amino-1-butanol → HCID 25213975, compound

HRID 2382832Notes

Reaction equation

HRID 2382832 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[NH2:20][CH:21]([CH2:24][CH3:25])[CH2:22][OH:23]>>[OH:23][CH2:22][CH:21]([NH:20][C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1)[CH2:24][CH3:25]

Participants

3

Reactant 2

HCID 221292-Amino-1-butanolHCID 25212515HCID 25212515, compound

Product 1

HCID 25213975HCID 25213975, compound

Procedure

The title compound was prepared following procedure described for example 30, but starting from N-(5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)benzamide ((B3), 52 mg; 0.19 mmol; 1.0 eq.) and 2-amino-1-butanol (0.2 mL) as a white powder (13 mg, 22%). HPLC, Rt: 2.25 min. (purity 90.7%). LC/MS, M+(ESI): 326.2.

Sources & evidence

ORD record
ord-a753babd3a3c4da2987c9c7a04405550
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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