4-(((tert-Butoxycarbonyl)amino)methyl)benzoic acid → HCID 59437557, compound

HRID 2382834Notes

Reaction equation

HRID 2382834 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[CH3:16][C:17]([O:20][C:21]([NH:23][CH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31](O)=[O:32])=[CH:27][CH:26]=1)=[O:22])([CH3:19])[CH3:18]>>[C:17]([O:20][C:21](=[O:22])[NH:23][CH2:24][C:25]1[CH:26]=[CH:27][C:28]([C:31]([NH:15][C:13]2[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=[C:6]([C:3]4[CH:4]=[CH:5][O:1][CH:2]=4)[N:11]3[N:12]=2)=[O:32])=[CH:29][CH:30]=1)([CH3:19])([CH3:16])[CH3:18]

Participants

3

Reactant 2

HCID 8536054-(((tert-Butoxycarbonyl)amino)methyl)benzoic acidHCID 252159385-(Furan-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 59437557HCID 59437557, compound

Procedure

The title compound was prepared following procedure and work up described for example 2, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 75 mg; 0.37 mmol; 1.0 eq.) and boc-(4-aminomethyl)-benzoic acid (113 mg; 0.45 mmol; 1.2 eq.) as a white foam (35.4 mg, 22%). HPLC, Rt: 3.69 min. (purity 88.9%). LC/MS, M+(ESI): 434.1, M−(ESI): 432.1.

Sources & evidence

ORD record
ord-f3368c4c6e794ef59496eae02f32758a
Source dataset
uspto-grants-2012_09
Patent number
US08263595B2

Reaction notes

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